Having just outlined proper conduct which the Thessalonians should be careful to observe, Paul moved to prayers on their behalf. Such conduct is the process of sanctification. As we grow closer to God by gaining a fuller knowledge of Him and His will, and by subsequent participation in His will, we are being further set apart by Him, and for Him. The purpose for which He called us and saved us is being brought closer to completion as we are compliant with His will. This is His work in us – “for it is God who works in you both to will and to do for His good pleasure” (Philippians 2:13).

In the same vein, our entire person is being “preserved blameless” by God as we adhere to His will. It is necessary that we be found “blameless” at the coming of Christ to enjoy the promises discussed before (cf. 4:13-18). This sanctification and preservation of blamelessness is accomplished by God in the entirety of man. There is no part of the Christian which is exempt from, or left out of subservience to God’s will. Some attempt to explain the distinction between “spirit, [and] soul.” The use of the two together in this verse suggests a distinction, however, the explanation of such is a difficult task. The Hebrew writer showed such was difficult when he used the separation of the two by the word of God to show its power, and keen edge (cf. Hebrews 4:11-13). The point remains that, if we do our part we are called to do, God is faithful regarding His part, and will complete our sanctification, and preserve our entire being blameless.

Paul asked for prayers from the brethren, as he often did. He then exhorted the brethren to show brotherly love by participating in the custom of the time, greeting by a kiss. The display of brotherly affection may vary from culture to culture, but is expected, and is always to be holy. Paul then noted the importance of this epistle in his charge that it be read to everyone. Scripture is pertinent to each Christian’s salvation. Without knowing it we cannot live it. Lastly, as was his normal practice, Paul extended his wish of God’s grace upon the brethren. Without it we would utterly fail.